Exploring the Chemical Space of Multitarget Ligands Using Aligned Self-Organizing Maps

[Image: see text] Design of multitarget drugs and polypharmacological compounds has become popular during the past decade. However, the main approach to design such compounds is to link two selective ligands via a flexible linker. Although such chimeric ligands often have reasonable potency in vitro...

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Detalhes bibliográficos
Main Authors: Achenbach, Janosch, Klingler, Franca-Maria, Blöcher, René, Moser, Daniel, Häfner, Ann-Kathrin, Rödl, Carmen B., Kretschmer, Simon, Krüger, Björn, Löhr, Frank, Stark, Holger, Hofmann, Bettina, Steinhilber, Dieter, Proschak, Ewgenij
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2013
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027374/
https://ncbi.nlm.nih.gov/pubmed/24900624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml4002562
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