Low Doses of Allyphenyline and Cyclomethyline, Effective against Morphine Dependence, Elicit an Antidepressant-like Effect

[Image: see text] This study demonstrated that cyclomethyline (2) and the corresponding enantiomers (R)-(−)-2 and (S)-(+)-2, displaying α(2C)-adrenoreceptor (AR) agonism/α(2A)-AR antagonism, similarly to allyphenyline (1) and its enantiomers, significantly decreased the naloxone-precipitated withdra...

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Autors principals: Del Bello, Fabio, Diamanti, Eleonora, Giannella, Mario, Mammoli, Valerio, Marchioro, Carla, Mattioli, Laura, Titomanlio, Federica, Piergentili, Alessandro, Quaglia, Wilma, Benedetti, Giovanni, Varrone, Maurizio, Pigini, Maria
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2012
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025786/
https://ncbi.nlm.nih.gov/pubmed/24900506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300064v
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