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Synthesis of New Hydrophilic and Hydrophobic Cobinamides as NO-Independent sGC Activators
[Image: see text] Herein, the synthesis of novel hydrophobic and hydrophilic cobinamides via aminolysis of vitamin B(12) derivatives that activate soluble guanyl cyclase (sGC) is presented. Unlike other sGC regulators, they target the catalytic domain of sGC and show higher activity than (CN)(2)Cbi.
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American
Chemical Society
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4025757/ https://ncbi.nlm.nih.gov/pubmed/24900497 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300060n |
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