Neuroprotective Tri- and Tetracyclic BChE Inhibitors Releasing Reversible Inhibitors upon Carbamate Transfer

[Image: see text] Tri- and tetracyclic nitrogen-bridgehead compounds were designed and synthesized to yield micromolar cholinesterase (ChE) inhibitors. Structure–activity relationships identified potent compounds with butyrylcholinesterase selectivity. These compounds were selected as starting point...

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Hlavní autoři: Darras, Fouad H., Kling, Beata, Heilmann, Jörg, Decker, Michael
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2012
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025739/
https://ncbi.nlm.nih.gov/pubmed/24900407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml3001825
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