Novel Benzene-Based Carbamates for AChE/BChE Inhibition: Synthesis and Ligand/Structure-Oriented SAR Study

A series of new benzene-based derivatives was designed, synthesized and comprehensively characterized. All of the tested compounds were evaluated for their in vitro ability to potentially inhibit the acetyl- and butyrylcholinesterase enzymes. The selectivity index of individual molecules to cholines...

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Publicat a:Int J Mol Sci
Autors principals: Bak, Andrzej, Kozik, Violetta, Kozakiewicz, Dariusz, Gajcy, Kamila, Strub, Daniel Jan, Swietlicka, Aleksandra, Stepankova, Sarka, Imramovsky, Ales, Polanski, Jaroslaw, Smolinski, Adam, Jampilek, Josef
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6479915/
https://ncbi.nlm.nih.gov/pubmed/30934674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20071524
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