Strategy for Imidazotetrazine Prodrugs with Anticancer Activity Independent of MGMT and MMR

[Image: see text] The imidazotetrazine ring is an acid-stable precursor and prodrug of highly reactive alkyl diazonium ions. We have shown that this reactivity can be managed productively in an aqueous system for the generation of aziridinium ions with 96% efficiency. The new compounds are potent DN...

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Bibliografiske detaljer
Main Authors: Garelnabi, Elrashied A. E., Pletsas, Dimitrios, Li, Li, Kiakos, Konstantinos, Karodia, Nazira, Hartley, John A., Phillips, Roger M., Wheelhouse, Richard T.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2012
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025673/
https://ncbi.nlm.nih.gov/pubmed/24900418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300132t
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