GFRα1 released by nerves enhances cancer cell perineural invasion through GDNF-RET signaling

The ability of cancer cells to invade along nerves is associated with aggressive disease and diminished patient survival rates. Perineural invasion (PNI) may be mediated by nerve secretion of glial cell line-derived neurotrophic factor (GDNF) attracting cancer cell migration through activation of ce...

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Hlavní autoři: He, Shuangba, Chen, Chun-Hao, Chernichenko, Natalya, He, Shizhi, Bakst, Richard L., Barajas, Fernando, Deborde, Sylvie, Allen, Peter J., Vakiani, Efsevia, Yu, Zhenkun, Wong, Richard J.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2014
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4024863/
https://ncbi.nlm.nih.gov/pubmed/24778213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1402944111
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