Age-associated abnormalities of intrinsic automaticity of sinoatrial nodal cells are linked to deficient cAMP-PKA-Ca(2+) signaling

A reduced sinoatrial node (SAN) functional reserve underlies the age-associated decline in heart rate acceleration in response to stress. SAN cell function involves an oscillatory coupled-clock system: the sarcoplasmic reticulum (SR), a Ca(2+) clock, and the electrogenic-sarcolemmal membrane clock....

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Hlavní autoři: Liu, Jie, Sirenko, Syevda, Juhaszova, Magdalena, Sollott, Steven J., Shukla, Shweta, Yaniv, Yael, Lakatta, Edward G.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4024720/
https://ncbi.nlm.nih.gov/pubmed/24633551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00088.2014
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