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A TALEN-based strategy for efficient bi-allelic miRNA ablation in human cells
Significant progress in the functional understanding of microRNAs (miRNAs) has been made in mice, but a need remains to develop efficient tools for bi-allelic knockouts of miRNA in the human genome. Transcription activator-like effector nucleases (TALENs) provide an exciting platform for targeted ge...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Cold Spring Harbor Laboratory Press
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4024647/ https://ncbi.nlm.nih.gov/pubmed/24717974 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.042010.113 |
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