MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration

Subsets of rodent neurons are reported to express major histocompatibilty complex class I (MHC-I), but such expression has not been reported in normal adult human neurons. Here we provide evidence from immunolabel, RNA expression, and mass spectrometry analysis of postmortem samples that human catec...

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Hauptverfasser: Cebrián, Carolina, Zucca, Fabio A., Mauri, Pierluigi, Steinbeck, Julius A., Studer, Lorenz, Scherzer, Clemens R., Kanter, Ellen, Budhu, Sadna, Mandelbaum, Jonathan, Vonsattel, Jean P., Zecca, Luigi, Loike, John D., Sulzer, David
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4024461/
https://ncbi.nlm.nih.gov/pubmed/24736453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4633
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