The Effect of Substrate Topography on Direct Reprogramming of Fibroblasts to Induced Neurons

Cellular reprogramming holds tremendous potential for cell therapy and regenerative medicine. Recently, fibroblasts have been directly converted into induced neurons (iNs) by overexpression of the neuronal transcription factors Ascl1, Brn2 and Myt1L. Hypothesizing that cell-topography interactions c...

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Detalhes bibliográficos
Main Authors: Kulangara, Karina, Adler, Andrew F., Wang, Hong, Chellappan, Malathi, Hammett, Ellen, Yasuda, Ryohei, Leong, Kam W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023960/
https://ncbi.nlm.nih.gov/pubmed/24709523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2014.03.034
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