Mapping Pathological Phenotypes in a Mouse Model of CDKL5 Disorder

Mutations in cyclin-dependent kinase-like 5 (CDKL5) cause early-onset epileptic encephalopathy, a neurodevelopmental disorder with similarities to Rett Syndrome. Here we describe the physiological, molecular, and behavioral phenotyping of a Cdkl5 conditional knockout mouse model of CDKL5 disorder. B...

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Main Authors: Amendola, Elena, Zhan, Yang, Mattucci, Camilla, Castroflorio, Enrico, Calcagno, Eleonora, Fuchs, Claudia, Lonetti, Giuseppina, Silingardi, Davide, Vyssotski, Alexei L., Farley, Dominika, Ciani, Elisabetta, Pizzorusso, Tommaso, Giustetto, Maurizio, Gross, Cornelius T.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2014
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023934/
https://ncbi.nlm.nih.gov/pubmed/24838000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0091613
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