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Phase I, Open-Label, Safety and Pharmacokinetic Study To Assess Bronchopulmonary Disposition of Intravenous Eravacycline in Healthy Men and Women

This study evaluated the pulmonary disposition of eravacycline in 20 healthy adult volunteers receiving 1.0 mg of eravacycline/kg intravenously every 12 h for a total of seven doses over 4 days. Plasma samples were collected at 0, 1, 2, 4, 6, and 12 h on day 4, with each subject randomized to underg...

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Autors principals: Connors, Kevin P., Housman, Seth T., Pope, J. Samuel, Russomanno, John, Salerno, Edward, Shore, Eric, Redican, Susan, Nicolau, David P.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023791/
https://ncbi.nlm.nih.gov/pubmed/24468780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02036-13
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