Isavuconazole Therapy Protects Immunosuppressed Mice from Mucormycosis

We studied the in vitro and in vivo efficacies of the investigational drug isavuconazole against mucormycosis due to Rhizopus delemar. Isavuconazole was effective, with MIC and minimal fungicidal concentration (MFC) values ranging between 0.125 and 1.00 μg/ml. A high dose of isavuconazole prolonged...

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Bibliographic Details
Main Authors: Luo, Guanpingsheng, Gebremariam, Teclegiorgis, Lee, Hongkyu, Edwards, John E., Kovanda, Laura, Ibrahim, Ashraf S.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023778/
https://ncbi.nlm.nih.gov/pubmed/24492363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02301-13
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