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Identification of a Key Lysine Residue in Heat Shock Protein 90 Required for Azole and Echinocandin Resistance in Aspergillus fumigatus

Heat shock protein 90 (Hsp90) is an essential chaperone involved in the fungal stress response that can be harnessed as a novel antifungal target for the treatment of invasive aspergillosis. We previously showed that genetic repression of Hsp90 reduced Aspergillus fumigatus virulence and potentiated...

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Main Authors: Lamoth, Frédéric, Juvvadi, Praveen R., Soderblom, Erik J., Moseley, M. Arthur, Asfaw, Yohannes G., Steinbach, William J.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2014
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023766/
https://ncbi.nlm.nih.gov/pubmed/24395240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02286-13
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