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Transcriptional Activation of Heat Shock Protein 90 Mediated Via a Proximal Promoter Region as Trigger of Caspofungin Resistance in Aspergillus fumigatus

Invasive aspergillosis is a deadly infection for which new antifungal therapies are needed. Heat shock protein 90 (Hsp90) is an essential chaperone in Aspergillus fumigatus representing an attractive antifungal target. Using a thiamine-repressible promoter (pthiA), we showed that genetic repression...

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Bibliografske podrobnosti
Main Authors: Lamoth, Frédéric, Juvvadi, Praveen R., Gehrke, Christopher, Asfaw, Yohannes G., Steinbach, William J.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3883176/
https://ncbi.nlm.nih.gov/pubmed/24096332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jit530
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