Common polymorphisms of ALOX5 and ALOX5AP and risk of coronary artery disease

Recent human genetic studies suggest that allelic variants of leukotriene pathway genes influence the risk of clinical and subclinical atherosclerosis. We sequenced the promoter, exonic, and splice site regions of ALOX5 and ALOX5AP and then genotyped 7 SNPs in ALOX5 and 6 SNPs in ALOX5AP in 1,552 ca...

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Hauptverfasser: Assimes, Themistocles L., Knowles, Joshua W., Priest, Jame s R., Basu, Analabha, Volcik, Kelly A., Southwick, Audrey, Tabor, Holly K., Hartiala, Jaana, Allayee, Hooman, Grove, Megan L., Tabibiazar, Raymond, Sidney, Stephen, Fortmann, Stephen P., Go, Alan, Hlatky, Mark, Iribarren, Carlos, Boerwinkle, Eric, Myers, Richard, Risch, Neil, Quertermous, Thomas
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023692/
https://ncbi.nlm.nih.gov/pubmed/18369664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00439-008-0489-5
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