A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease: Assimes T560M in ALOX15 and the risk of CAD

OBJECTIVE: Murine genetic models suggest that function of the 12/15 LOX enzyme promotes atherosclerosis. We tested the hypothesis that exonic and/or promoter single nucleotide polymorphisms (SNPs) in the human 12/15-LOX gene (ALOX15) alter the risk of symptomatic coronary artery disease (CAD). METHO...

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Main Authors: Assimes, Themistocles L., Knowles, Joshua W., Priest, James R., Basu, Analabha, Borchert, Astrid, Volcik, Kelly A., Grove, Megan L., Tabor, Holly K., Southwick, Audrey, Tabibiazar, Raymond, Sidney, Steve, Boerwinkle, Eric, Go, Alan S., Iribarren, Carlos, Hlatky, Mark A., Fortmann, Stephen P., Myers, Richard M., Kuhn, Hartmut, Risch, Neil, Quertermous, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2440699/
https://ncbi.nlm.nih.gov/pubmed/17959182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.atherosclerosis.2007.09.003
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