A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease: Assimes T560M in ALOX15 and the risk of CAD

OBJECTIVE: Murine genetic models suggest that function of the 12/15 LOX enzyme promotes atherosclerosis. We tested the hypothesis that exonic and/or promoter single nucleotide polymorphisms (SNPs) in the human 12/15-LOX gene (ALOX15) alter the risk of symptomatic coronary artery disease (CAD). METHO...

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Hlavní autoři: Assimes, Themistocles L., Knowles, Joshua W., Priest, James R., Basu, Analabha, Borchert, Astrid, Volcik, Kelly A., Grove, Megan L., Tabor, Holly K., Southwick, Audrey, Tabibiazar, Raymond, Sidney, Steve, Boerwinkle, Eric, Go, Alan S., Iribarren, Carlos, Hlatky, Mark A., Fortmann, Stephen P., Myers, Richard M., Kuhn, Hartmut, Risch, Neil, Quertermous, Thomas
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2440699/
https://ncbi.nlm.nih.gov/pubmed/17959182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.atherosclerosis.2007.09.003
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