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Synthesis of a C-phosphonate mimic of maltose-1-phosphate and inhibition studies on Mycobacterium tuberculosis GlgE

The emergence of extensively drug-resistant tuberculosis (XDR-TB) necessitates the need to identify new anti-tuberculosis drug targets as well as to better understand essential biosynthetic pathways. GlgE is a Mycobacterium tuberculosis (Mtb) encoded maltosyltransferase involved in α-glucan biosynth...

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Autori principali: Veleti, Sri Kumar, Lindenberger, Jared J., Ronning, Donald R., Sucheck, Steven J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023634/
https://ncbi.nlm.nih.gov/pubmed/24461562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.12.058
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