A functional screen for copper homeostasis genes identifies a pharmacologically tractable cellular system

BACKGROUND: Copper is essential for the survival of aerobic organisms. If copper is not properly regulated in the body however, it can be extremely cytotoxic and genetic mutations that compromise copper homeostasis result in severe clinical phenotypes. Understanding how cells maintain optimal copper...

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Main Authors: Schlecht, Ulrich, Suresh, Sundari, Xu, Weihong, Aparicio, Ana Maria, Chu, Angela, Proctor, Michael J, Davis, Ronald W, Scharfe, Curt, St Onge, Robert P
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023593/
https://ncbi.nlm.nih.gov/pubmed/24708151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-15-263
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