Atrogin-1 and MuRF1 regulate cardiac MyBP-C levels via different mechanisms

AIMS: Familial hypertrophic cardiomyopathy (FHC) is frequently caused by cardiac myosin-binding protein C (cMyBP-C) gene mutations, which should result in C-terminal truncated mutants. However, truncated mutants were not detected in myocardial tissue of FHC patients and were rapidly degraded by the...

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Hlavní autoři: Mearini, Giulia, Gedicke, Christina, Schlossarek, Saskia, Witt, Christian C., Krämer, Elisabeth, Cao, Peirang, Gomes, Marcelo D., Lecker, Stewart H., Labeit, Siegfried, Willis, Monte S., Eschenhagen, Thomas, Carrier, Lucie
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2010
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023316/
https://ncbi.nlm.nih.gov/pubmed/19850579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvp348
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