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Genome-wide analysis of parent-of-origin effects in non-syndromic orofacial clefts

Parent-of-origin (PofO) effects, such as imprinting are a phenomenon where the effect of variants depends on parental origin. Conventional association studies assume that phenotypic effects are independent of parental origin, and are thus severely underpowered to detect such non-Mendelian effects. R...

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Detalhes bibliográficos
Main Authors: Garg, Paras, Ludwig, Kerstin U, Böhmer, Anne C, Rubini, Michele, Steegers-Theunissen, Regine, Mossey, Peter A, Mangold, Elisabeth, Sharp, Andrew J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023210/
https://ncbi.nlm.nih.gov/pubmed/24169523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2013.235
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