Interleukin-12 (IL-12p70) Promotes Induction of Highly Potent Th1-Like CD4(+)CD25(+) T Regulatory Cells That Inhibit Allograft Rejection in Unmodified Recipients

In rat models, CD4(+)CD25(+) T regulatory cells (Treg) play a key role in the induction and maintenance of antigen-specific transplant tolerance, especially in DA rats with PVG cardiac allografts (1, 2). We have previously described generation of alloantigen-specific Treg (Ts1), by culture of naïve...

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Autors principals: Verma, Nirupama Darshan, Hall, Bruce Milne, Plain, Karren Michelle, Robinson, Catherine M., Boyd, Rochelle, Tran, Giang T., Wang, Chuanmin, Bishop, G. Alex, Hodgkinson, Suzanne J.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2014
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023029/
https://ncbi.nlm.nih.gov/pubmed/24847323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2014.00190
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