Linker Length Matters, Fynomer-Fc Fusion with an Optimized Linker Displaying Picomolar IL-17A Inhibition Potency

Fynomers are small binding proteins derived from the human Fyn SH3 domain. Using phage display technology, Fynomers were generated inhibiting the activity of the proinflammatory cytokine interleukin-17A (IL-17A). One specific Fynomer called 2C1 inhibited human IL-17A in vitro with an IC(50) value of...

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Detalhes bibliográficos
Main Authors: Silacci, Michela, Baenziger-Tobler, Nadja, Lembke, Wibke, Zha, Wenjuan, Batey, Sarah, Bertschinger, Julian, Grabulovski, Dragan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4022905/
https://ncbi.nlm.nih.gov/pubmed/24692552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.534578
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