Shiga Toxin Subtypes Display Dramatic Differences in Potency

Purified Shiga toxin (Stx) alone is capable of producing systemic complications, including hemolytic-uremic syndrome (HUS), in animal models of disease. Stx includes two major antigenic forms (Stx1 and Stx2), with minor variants of Stx2 (Stx2a to -h). Stx2a is more potent than Stx1. Epidemiologic st...

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Bibliographic Details
Main Authors: Fuller, Cynthia A., Pellino, Christine A., Flagler, Michael J., Strasser, Jane E., Weiss, Alison A.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2011
Subjects:
Molecular Pathogenesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067513/
https://ncbi.nlm.nih.gov/pubmed/21199911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01182-10
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