Evidence for Follicle-stimulating Hormone Receptor as a Functional Trimer

Follicle-stimulating hormone receptor (FSHR), a G-protein coupled receptor, is an important drug target in the development of novel therapeutics for reproductive indications. The FSHR extracellular domains were observed in the crystal structure as a trimer, which enabled us to propose a novel model...

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Main Authors: Jiang, Xuliang, Fischer, David, Chen, Xiaoyan, McKenna, Sean D., Liu, Heli, Sriraman, Venkataraman, Yu, Henry N., Goutopoulos, Andreas, Arkinstall, Steve, He, Xiaolin
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4022893/
https://ncbi.nlm.nih.gov/pubmed/24692546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.549592
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