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Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor

FSH, a glycoprotein hormone, and the FSH receptor (FSHR), a G protein-coupled receptor, play central roles in human reproduction. We report the crystal structure of FSH in complex with the entire extracellular domain of FSHR (FSHR(ED)), including the enigmatic hinge region that is responsible for si...

תיאור מלא

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מידע ביבליוגרפי
Main Authors: Jiang, Xuliang, Liu, Heli, Chen, Xiaoyan, Chen, Po-Han, Fischer, David, Sriraman, Venkataraman, Yu, Henry N., Arkinstall, Steve, He, Xiaolin
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411987/
https://ncbi.nlm.nih.gov/pubmed/22802634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206643109
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