Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor

FSH, a glycoprotein hormone, and the FSH receptor (FSHR), a G protein-coupled receptor, play central roles in human reproduction. We report the crystal structure of FSH in complex with the entire extracellular domain of FSHR (FSHR(ED)), including the enigmatic hinge region that is responsible for si...

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Библиографические подробности
Главные авторы: Jiang, Xuliang, Liu, Heli, Chen, Xiaoyan, Chen, Po-Han, Fischer, David, Sriraman, Venkataraman, Yu, Henry N., Arkinstall, Steve, He, Xiaolin
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2012
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411987/
https://ncbi.nlm.nih.gov/pubmed/22802634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206643109
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