Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor

FSH, a glycoprotein hormone, and the FSH receptor (FSHR), a G protein-coupled receptor, play central roles in human reproduction. We report the crystal structure of FSH in complex with the entire extracellular domain of FSHR (FSHR(ED)), including the enigmatic hinge region that is responsible for si...

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Detalhes bibliográficos
Main Authors: Jiang, Xuliang, Liu, Heli, Chen, Xiaoyan, Chen, Po-Han, Fischer, David, Sriraman, Venkataraman, Yu, Henry N., Arkinstall, Steve, He, Xiaolin
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411987/
https://ncbi.nlm.nih.gov/pubmed/22802634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206643109
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