Divergent Transducer-specific Molecular Efficacies Generate Biased Agonism at a G Protein-coupled Receptor (GPCR)

The concept of “biased agonism” arises from the recognition that the ability of an agonist to induce a receptor-mediated response (i.e. “efficacy”) can differ across the multiple signal transduction pathways (e.g. G protein and β-arrestin (βarr)) emanating from a single GPCR. Despite the therapeutic...

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Autors principals: Strachan, Ryan T., Sun, Jin-peng, Rominger, David H., Violin, Jonathan D., Ahn, Seungkirl, Rojas Bie Thomsen, Alex, Zhu, Xiao, Kleist, Andrew, Costa, Tommaso, Lefkowitz, Robert J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2014
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4022887/
https://ncbi.nlm.nih.gov/pubmed/24668815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.548131
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