Conformational Profiling of the AT1 Angiotensin II Receptor Reflects Biased Agonism, G Protein Coupling, and Cellular Context

Here, we report the design and use of G protein-coupled receptor-based biosensors to monitor ligand-mediated conformational changes in receptors in intact cells. These biosensors use bioluminescence resonance energy transfer with Renilla luciferase (RlucII) as an energy donor, placed at the distal e...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Devost, Dominic, Sleno, Rory, Pétrin, Darlaine, Zhang, Alice, Shinjo, Yuji, Okde, Rakan, Aoki, Junken, Inoue, Asuka, Hébert, Terence E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2017
Soggetti:
Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392687/
https://ncbi.nlm.nih.gov/pubmed/28213525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.763854
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