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Plk1 Protein Phosphorylates Phosphatase and Tensin Homolog (PTEN) and Regulates Its Mitotic Activity during the Cell Cycle

PTEN is a well known tumor suppressor through the negative regulation of the PI3K signaling pathway. Here we report that PTEN plays an important role in regulating mitotic timing, which is associated with increased PTEN phosphorylation in the C-terminal tail and its localization to chromatin. Pulldo...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Choi, Byeong Hyeok, Pagano, Michele, Dai, Wei
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4022876/
https://ncbi.nlm.nih.gov/pubmed/24706748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.558155
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