Critical Role of Aquaporins in Interleukin 1β (IL-1β)-induced Inflammation

Rapid changes in cell volume characterize macrophage activation, but the role of water channels in inflammation remains unclear. We show here that, in vitro, aquaporin (AQP) blockade or deficiency results in reduced IL-1β release by macrophages activated with a variety of NLRP3 activators. Inhibitio...

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Detalhes bibliográficos
Main Authors: Rabolli, Virginie, Wallemme, Laurent, Lo Re, Sandra, Uwambayinema, Francine, Palmai-Pallag, Mihaly, Thomassen, Leen, Tyteca, Donatienne, Octave, Jean-Noel, Marbaix, Etienne, Lison, Dominique, Devuyst, Olivier, Huaux, François
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4022865/
https://ncbi.nlm.nih.gov/pubmed/24700466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.534594
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