The alarmin IL-1α is a master cytokine in acute lung inflammation induced by silica micro- and nanoparticles

BACKGROUND: Inflammasome-activated IL-1β plays a major role in lung neutrophilic inflammation induced by inhaled silica. However, the exact mechanisms that contribute to the initial production of precursor IL-1β (pro-IL-1β) are still unclear. Here, we assessed the implication of alarmins (IL-1α, IL-...

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Veröffentlicht in:Part Fibre Toxicol
Hauptverfasser: Rabolli, Virginie, Badissi, Anissa Alami, Devosse, Raynal, Uwambayinema, Francine, Yakoub, Yousof, Palmai-Pallag, Mihaly, Lebrun, Astrid, De Gussem, Valentin, Couillin, Isabelle, Ryffel, Bernard, Marbaix, Etienne, Lison, Dominique, Huaux, François
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2014
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4279463/
https://ncbi.nlm.nih.gov/pubmed/25497724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12989-014-0069-x
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