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The Tetraspanin CD53 Modulates Responses from Activating NK Cell Receptors, Promoting LFA-1 Activation and Dampening NK Cell Effector Functions

NK cells express several tetraspanin proteins, which differentially modulate NK cell activities. The tetraspanin CD53 is expressed by all resting NK cells and was previously shown to decrease NK cell cytotoxicity upon ligation. Here, we show that CD53 ligation reduced degranulation of rat NK cells i...

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Detalhes bibliográficos
Main Authors: Todros-Dawda, Izabela, Kveberg, Lise, Vaage, John T., Inngjerdingen, Marit
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4022634/
https://ncbi.nlm.nih.gov/pubmed/24832104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0097844
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