CD44 standard and CD44v10 isoform expression on leukemia cells distinctly influences niche embedding of hematopoietic stem cells

BACKGROUND: A blockade of CD44 is considered a therapeutic option for the elimination of leukemia initiating cells. However, anti-panCD44 can interfere with hematopoiesis. Therefore we explored, whether a CD44 variant isoform (CD44v)-specific antibody can inhibit leukemia growth without attacking he...

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Autori principali: Erb, Ulrike, Megaptche, Amelie Pajip, Gu, Xiaoyu, Büchler, Markus W, Zöller, Margot
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2014
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4022365/
https://ncbi.nlm.nih.gov/pubmed/24684724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8722-7-29
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