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CD44 Staining of Cancer Stem-Like Cells Is Influenced by Down-Regulation of CD44 Variant Isoforms and Up-Regulation of the Standard CD44 Isoform in the Population of Cells That Have Undergone Epithelial-to-Mesenchymal Transition

CD44 is commonly used as a cell surface marker of cancer stem-like cells in epithelial tumours, and we have previously demonstrated the existence of two different CD44(high) cancer stem-like cell populations in squamous cell carcinoma, one having undergone epithelial-to-mesenchymal transition and th...

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Autors principals: Biddle, Adrian, Gammon, Luke, Fazil, Bilal, Mackenzie, Ian C.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3577706/
https://ncbi.nlm.nih.gov/pubmed/23437366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0057314
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