Transcriptional regulation of Caenorhabditis elegans FOXO/DAF-16 modulates lifespan

BACKGROUND: Insulin/IGF-1 signaling plays a central role in longevity across phylogeny. In C. elegans, the forkhead box O (FOXO) transcription factor, DAF-16, is the primary target of insulin/IGF-1 signaling, and multiple isoforms of DAF-16 (a, b, and d/f) modulate lifespan, metabolism, dauer format...

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Autori principali: Bansal, Ankita, Kwon, Eun-Soo, Conte, Darryl, Liu, Haibo, Gilchrist, Michael J, MacNeil, Lesley T, Tissenbaum, Heidi A
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2014
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4022319/
https://ncbi.nlm.nih.gov/pubmed/24834345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2046-2395-3-5
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