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Asynchronous transcriptional silencing of individual retroviral genomes in embryonic cells

BACKGROUND: Retroviral DNAs are profoundly silenced at the transcriptional level in embryonic cell types. The transcriptional profile of pluripotent stem cells has been demonstrated to be extremely heterogeneous from cell to cell, and how the silencing of retroviral DNAs is achieved is not yet well...

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Autores principales: Schlesinger, Sharon, Meshorer, Eran, Goff, Stephen P
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4021621/
https://ncbi.nlm.nih.gov/pubmed/24742368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-11-31
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