Andrographolide attenuates skeletal muscle dystrophy in mdx mice and increases efficiency of cell therapy by reducing fibrosis

BACKGROUND: Duchenne muscular dystrophy (DMD) is characterized by the absence of the cytoskeletal protein dystrophin, muscle wasting, increased transforming growth factor type beta (TGF-β) signaling, and fibrosis. At the present time, the only clinically validated treatments for DMD are glucocortico...

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Main Authors: Cabrera, Daniel, Gutiérrez, Jaime, Cabello-Verrugio, Claudio, Morales, Maria Gabriela, Mezzano, Sergio, Fadic, Ricardo, Casar, Juan Carlos, Hancke, Juan L, Brandan, Enrique
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2014
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4021597/
https://ncbi.nlm.nih.gov/pubmed/24655808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2044-5040-4-6
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