The Bcl-2/xL inhibitor ABT-263 increases the stability of Mcl-1 mRNA and protein in hepatocellular carcinoma cells

BACKGROUND: Hepatocellular carcinoma (HCC) is one of the major causes of mortality. ABT-263 is a newly synthesized, orally available Bcl-2/xL inhibitor that shows promising efficacy in HCC therapy. ABT-263 inhibits the anti-apoptotic activity of Bcl-2 and Bcl-xL, but not Mcl-1. Previous reports have...

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Bibliografiske detaljer
Main Authors: Wang, Bin, Ni, Zhenhong, Dai, Xufang, Qin, Liyan, Li, Xinzhe, Xu, Liang, Lian, Jiqin, He, Fengtian
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4021276/
https://ncbi.nlm.nih.gov/pubmed/24779770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-98
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