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[Val12] HRAS downregulates GLUT2 in beta cells of transgenic mice without affecting glucose homeostasis.
Glucose-induced insulin release from pancreatic beta cells depends on the beta-cell metabolism of glucose, which generates intracellular signals for secretion. The beta-cell glucose transporter isotype GLUT2 and the glucose phosphorylating enzyme glucokinase have both been implicated in coupling ins...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1992
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC402094/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1631055/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.13.5744 |
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