A DNA Sequence Recognition Loop on APOBEC3A Controls Substrate Specificity

APOBEC3A (A3A), one of the seven-member APOBEC3 family of cytidine deaminases, lacks strong antiviral activity against lentiviruses but is a potent inhibitor of adeno-associated virus and endogenous retroelements. In this report, we characterize the biochemical properties of mammalian cell-produced...

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Detalhes bibliográficos
Main Authors: Logue, Eric C., Bloch, Nicolin, Dhuey, Erica, Zhang, Ruonan, Cao, Ping, Herate, Cecile, Chauveau, Lise, Hubbard, Stevan R., Landau, Nathaniel R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4020817/
https://ncbi.nlm.nih.gov/pubmed/24827831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0097062
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