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Intramolecular Conformational Changes Optimize Protein Kinase C Signaling()
Optimal tuning of enzyme signaling is critical for cellular homeostasis. We use fluorescence resonance energy transfer reporters in live cells to follow conformational transitions that tune the affinity of a multi-domain signal transducer, protein kinase C, for optimal response to second messengers....
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4020788/ https://ncbi.nlm.nih.gov/pubmed/24631122 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2014.02.008 |
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