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Protein kinase C fusion proteins are paradoxically loss of function in cancer

Within the AGC kinase superfamily, gene fusions resulting from chromosomal rearrangements have been most frequently described for protein kinase C (PKC), with gene fragments encoding either the C-terminal catalytic domain or the N-terminal regulatory moiety fused to other genes. Kinase fusions that...

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Foilsithe in:J Biol Chem
Main Authors: Van, An-Angela N., Kunkel, Maya T., Baffi, Timothy R., Lordén, Gema, Antal, Corina E., Banerjee, Sourav, Newton, Alexandra C.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2021
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8008189/
https://ncbi.nlm.nih.gov/pubmed/33617877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100445
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