Ribozyme mediated destruction of RNA in vivo.

Previous studies have demonstrated that high ribozyme to substrate ratios are required for ribozyme inhibitory function in nuclear extracts. To obtain high intracellular levels of ribozymes, tRNA genes, known to be highly expressed in most tissues, have been modified for use as ribozyme expression c...

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Bibliographic Details
Published in:EMBO J
Main Authors: Cotten, M, Birnstiel, M L
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 1989
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC402074/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2684648/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1989.tb08564.x
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