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Increasing DNA repair methyltransferase levels via bone marrow stem cell transduction rescues mice from the toxic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea, a chemotherapeutic alkylating agent.

The chloroethylnitrosourea (CNU) alkylating agents are commonly used for cancer chemotherapy, but their usefulness is limited by severe bone marrow toxicity that causes the cumulative depletion of all hematopoietic lineages (pancytopenia). Bone marrow CNU sensitivity is probably due to the inefficie...

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Uloženo v:
Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Maze, R, Carney, J P, Kelley, M R, Glassner, B J, Williams, D A, Samson, L
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 1996
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40207/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8552605/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.1.206
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