Thalidomide Increases Human Hepatic Cytochrome P450 3A Enzymes by Direct Activation of Pregnane X Receptor

Heterotropic cooperativity of human cytochrome P450 (P450) 3A4/3A5 by the teratogen thalidomide was recently demonstrated by H. Yamazaki et al. (2013) using the model substrate midazolam in various in vitro and in vivo models. Chimeric mice with humanized liver also displayed enhanced midazolam clea...

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Hlavní autoři: Murayama, Norie, van Beuningen, Rinie, Suemizu, Hiroshi, Guillouzo, Christiane Guguen, Shibata, Norio, Yajima, Kanako, Utoh, Masahiro, Shimizu, Makiko, Chesné, Christophe, Nakamura, Masato, Guengerich, F. Peter, Houtman, René, Yamazaki, Hiroshi
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4020009/
https://ncbi.nlm.nih.gov/pubmed/24460184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx4004374
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