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Proteasomal interaction as a critical activity modulator of the human constitutive androstane receptor
The CAR (constitutive androstane receptor; NR1I3) is a critical xenobiotic sensor that regulates xenobiotic metabolism, drug clearance, energy and lipid homoeostasis, cell proliferation and development. Although constitutively active, in hepatocytes CAR is normally held quiescent through a tethering...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4019979/ https://ncbi.nlm.nih.gov/pubmed/24224465 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20130685 |
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