Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator

The constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are important nuclear receptors involved in the regulation of cellular responses from exposure to many xenobiotics and various physiological processes. Phenobarbital (PB) is a non-genotoxic indirect CAR activator, which induces...

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Main Authors: Elcombe, Clifford R., Peffer, Richard C., Wolf, Douglas C., Bailey, Jason, Bars, Remi, Bell, David, Cattley, Russell C., Ferguson, Stephen S., Geter, David, Goetz, Amber, Goodman, Jay I., Hester, Susan, Jacobs, Abigail, Omiecinski, Curtis J., Schoeny, Rita, Xie, Wen, Lake, Brian G.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019974/
https://ncbi.nlm.nih.gov/pubmed/24180433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10408444.2013.835786
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