Presynaptic glycine receptors as a potential therapeutic target for hyperekplexia disease

While postsynaptic GlyRs as α/β heteromers attract the most research attention, little is known about the role of presynaptic GlyRs, likely α homomers, in diseases. Here, we demonstrate that DH-CBD, a nonpsychoactive cannabinoid, can rescue GlyR functional deficiency and exaggerated acoustic and tac...

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Detalhes bibliográficos
Main Authors: Xiong, Wei, Chen, Shao-Rui, He, Liming, Cheng, Kejun, Zhao, Yi-Lin, Chen, Hong, Li, De-Pei, Homanics, Gregg E., Peever, John, Rice, Kenner C., Wu, Ling-gang, Pan, Hui-Lin, Zhang, Li
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019963/
https://ncbi.nlm.nih.gov/pubmed/24390226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3615
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