Deficient Import of Acetyl-CoA into the ER Lumen Causes Neurodegeneration and Propensity to Infections, Inflammation, and Cancer

The import of acetyl-CoA into the ER lumen by AT-1/SLC33A1 is essential for the N(ε)-lysine acetylation of ER-resident and ER-transiting proteins. A point-mutation (S113R) in AT-1 has been associated with a familial form of spastic paraplegia. Here, we report that AT-1(S113R) is unable to form homod...

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Autors principals: Peng, Yajing, Li, Mi, Clarkson, Ben D., Pehar, Mariana, Lao, Patrick J., Hillmer, Ansel T., Barnhart, Todd E., Christian, Bradley T., Mitchell, Heather A., Bendlin, Barbara B., Sandor, Matyas, Puglielli, Luigi
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2014
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019794/
https://ncbi.nlm.nih.gov/pubmed/24828632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0077-14.2014
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